Prestagen has developed a Plexamp kit allowing the detection of the most common human aneuploidies (chromosomes 13, 18, 21 X and Y). They include Bartholin-Patau syndrome or Trisomy 13 (approx. frequency: 0.5/10000 infants), Edwards syndrome or Trisomy 18 (approx. frequency: 1/10000 infants), Down syndrome or Trisomy 21 (approx. frequency: 1/800 infants), Klinefelter (or XXY) syndrome (approx. frequency: between 1/500 and 1/1000 male infants), XYY syndrome (between 1/900 and 1/2000 male infants) TriploX (or XXX) syndrome (approx. frequency: 1/1000 female infants), Turner (or X) syndrome (between 1/3000 and 1/5000 female infants).

Each target region is unique in the genome. Five target regions are located in each chromosome 13, 18 21 and X. Four target regions are located in chromosome Y.

Localization of PCR targets :

User manual PXT4