The MSH2 gene is located on chromosome 2p22, covers 159 kb and contains 16 exons. The MSH6 gene is located on chromosome 2p16, covers 26 kb and contains 10 exons. Constitutional abnormalities of these genes (which may range from point mutation to complex rearrangement) are generally associated with an increased risk of HNPCC (Hereditary Non Polyposis Colon Cancer).

The PXT3 kit allows the detection of quantitative genomic rearrangements of all sizes located in any region of the MSH2 gene (the primers target each of the 16 exons of the gene, the promoter region and the last exon of the EPCAM (or TACSTD1) gene located upstream to the MSH2 gene) and in most of the MSH6 gene (the primers target exons 2 to 10 of the gene).

MSH2 and MSH6 genomic maps (excluding intronic regions) :

: PLEXAMP targeted genomic regions

User manual PXT3